Glucocorticoid Receptor

Related Products

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Glucocorticoid Receptor Related Products (335)
Antibodies (4)

By Effects:	Controls (9) Ligands (5) Inhibitors (18) Agonists (179) Antagonists (20) Activators (13) Modulators (30)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B1832S

Prednisone acetate-d₃	Agonist
Prednisone acetate-d₃ is the deuterium labeled Prednisone acetate. Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties[1].

HY-14648S5

Dexamethasone-d₃-1	Agonist	98.02%
Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-100085S

21-Desacetyldeflazacort-d₅	Agonist	99.34%
21-Desacetyldeflazacort-d₅ is the deuterium labeled 21-Desacetyldeflazacort[1].

HY-125096

C108297	Modulator	99.97%
C108297 is a selective glucocorticoid receptor (GR) modulator (GR binding K_i 0.7 nM; GR reporter gene functional K_i 0.6 nM). C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation.

HY-B0625S

Ciclesonide-d₇	Agonist	99.99%
Ciclesonide-d₇ is the deuterium labeled Ciclesonide. Ciclesonide (RPR251526) is a glucocorticoid with an potent anti-inflammatory activity. Ciclesonide can be used for asthma research[1].

HY-159695

IONIS-GCCRRx	Antagonist
IONIS-GCCRRx (ISIS 426115), a glucocorticoid receptor antagonist, is a 2'-O-methoxyethyl (2'-MOE) antisense oligonucleotide (ASO).

HY-136340

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione	Agonist	99.93%
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization.

HY-160178

Glucocorticoid receptor agonist-3 Ala-Ala-Mal	Agonist	99.72%
Glucocorticoid receptor agonist-3 Ala-Ala-Mal (Compound Preparation 8) is an anti-human TNFα antibody-glucocorticoid receptor agonist (GC) conjugate. Glucocorticoid receptor agonist-3 Ala-Ala-Mal can be used in the study of autoimmune and inflammatory diseases.

HY-U00098

Prednisolone Tebutate	Modulator	99.82%
Prednisolone tebutate is a synthetic glucocorticoid used as an antiinflammatory and immunosuppressant.

HY-107939

Paramethasone Acetate		≥98.0%
Paramethasone acetate is a synthetic glucocorticoid, and shows anti-inflammatory and immunosuppressant activities.

HY-U00298

Amebucort	Modulator	≥99.0%
Amebucort is a synthetic glucocorticoid corticosteroid, may used for the research of inflammatory disorders.

HY-W778340

16α-Hydroxy-11-keto prednisolone	Control
16α-Hydroxy-11-keto prednisolone (compound M-X) is a metabolite of Budesonide (HY-13580). Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide is a widely used for study of asthma, rhinitis, and inflammatory bowel disease.

HY-111186

Flocoumafen		99.17%
Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandin F synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects.

HY-B1829AR

Dexamethasone phosphate (disodium) (Standard)	Agonist
Dexamethasone phosphate (disodium) (Standard) is the analytical standard of Dexamethasone phosphate (disodium). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is an orally active Glucocorticoid receptor agonist.

HY-15234S1

Fluticasone furoate-d₅	Activator	99.65%
Fluticasone furoate-d₅ is deuterium-labeled Fluticasone furoate (HY-15234).

HY-B0645R

Prednisolone disodium phosphate (Standard)	Agonist
Prednisolone (disodium phosphate) (Standard) is the analytical standard of Prednisolone (disodium phosphate). This product is intended for research and analytical applications.

HY-139556

Zavacorilant	Modulator
Zavacorilant is capable of modulating glucocorticoid receptor (GR).

HY-125839

OP-3633	Antagonist
OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC₅₀ of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism.

HY-13683S1

Mifepristone-¹³C,d₃	Antagonist
Mifepristone-¹³C,d₃ is the ¹³C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0154S1

Fluticasone propionate-d₅	Agonist
Fluticasone propionate-d₅ is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

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Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor Related Products (335)

Antibodies (4)

Glucocorticoid Receptor Related Products (335):